Prediction of protein-protein interactions
Members involvedFrancois Charih, Kevin Dick, Aishwarya Purohit, Eric Arezza
cuBIC participated actively in the development of the Protein-Protein Interaction Prediction Engine (PIPE) which was the first algorithm capable of generating the comprehensive human interactome. Today, PIPE is currently in its 4th iteration, and we are continuously trying to improve its performance, and trying to apply it to elucidate new interactomes such as that of human-SARS-CoV-2 for example.
In silico peptide design
Members involvedFrancois Charih
Peptide inhibitor display outstanding specificity for their target, and as such, show great potential as therapeutics through
disruption of protein-protein interactions and/or modulation of enzyme activity. Unfortunately, designing peptide inhibitors
in the wet lab is labour and resource-intensive. Recent developments in in silico peptide design (e.g. InSiPS) have made
it possible to generate active peptide therapeutics using only the primary sequence of the targeted protein as an input.
Unfortunately, such methods are slow and have suboptimal convergence.
Consistent with our core belief that collaboration across discipline is vital in the modern era, we initiated a partnership with the Biggar lab (biology) to develop a new method that integrates wet lab experiments (eg. peptide arrays) with computational methods in an iterative fashion to improve the state of the art in in silico peptide design.
Non-invasive monitoring of neonates in the NICU
Members involvedYasmina Souley Dosso, Samreen Aziz
We apply state of the art machine vision and pressure-sensitive mat (PSM) technologies to enable non-invasive monitoring of neonates in the NICU. As part of this research, conducted in collaboration with experts from the Children's Hospital of Eastern Ontario (CHEO), we develop apply existing and develop novel algorithms to analyze terabytes of RGB-depth imagery, and PSM data. We are interested in a variety of applications within this realm, including heart rate and respiratory rate estimation, event detection, false alarm reduction, etc.